Against the background of the new regulatory framework, this article reviews the varied experiences of selected programmes across the EU – the programmes that are part of the IQ-Net knowledge exchange network - with the fulfilment of the new monitoring requirements. The article is based on secondary source research and fieldwork interviews carried out in all the IQ-Net partner countries and regions with Managing Authorities and Intermediate Bodies, as well as an interview with the European Commission (DG REGIO). It starts with a review of the new monitoring obligations, and their rationale against the background of changed regulatory provisions. It then goes on to discuss the new monitoring arrangements in IQ-Net partner programmes, including the changes introduced to monitoring indicators and systems, the selection of results indicators, the main issues with the design and operation of the 2014-2020 monitoring systems, the challenges that remain to be addressed, as well as the additional efforts undertaken to supplement monitoring data with administrative and survey data, to better serve the needs of evaluation. Some concluding reflections are provided at the end of this paper.