The aim of the Investment Plan for Europe is to catalyse additional strategic investment in Europe’s key economic sectors. The rationale is to support higher risk projects that generate important and significant positive externalities, leveraging private sector participation and funding. The Investment Plan for Europe addresses the key challenges of the investment environment within the European Union (EU), while targeting investment projects that support EU policy priorities. Against this backdrop, this paper examines two of the Investment Plan’s key components, notably the European Fund for Strategic Investment (EFSI) and the European Investment Advisory Hub (EIAH), in conjunction with the Regional Policy objectives and financing via the European Structural Investment Funds (ESI Funds). We analyse the conceptual complementarities between these funding instruments and associated policies, explore the financial and implementation synergies, and note the practical limitations. Last, we highlight the role of the key stakeholders.